Orakl Oncology: How AI and Biology Are Revolutionizing Cancer Drug Development
Cancer rates continue to climb, with a concerning uptick among younger adults. Yet despite this growing need, most experimental drug compounds fail in clinical trials. French entrepreneur Fanny Jaulin believes the problem lies not with the drugs themselves, but with how we test them.
The Clinical Trial Conundrum
“A drug’s failure in trials doesn’t necessarily mean it’s ineffective,” Jaulin explains. “We need better methods to evaluate new molecules, particularly for cancers where treatment advances have stagnated.”
Her solution? Orakl Oncology, a startup that’s reimagining cancer drug development through a unique fusion of artificial intelligence and biological research.
Beyond AI: A Dual Approach to Cancer Research
While many companies are applying AI to drug discovery, Orakl stands apart by operating at the intersection of two critical domains:
- Data Science: Harnessing AI to account for each tumor’s unique characteristics
- Biology: Incorporating the fundamental complexity of cancer through tissue research
This hybrid approach mirrors industry leaders like Tempus while carving out its own niche in precision medicine.
The Science Behind the Solution
Orakl’s innovative platform combines:
- Patient avatars: Digital models merging real patient data with biological tissue
- Organoid technology: Miniature, simplified organ replicas for more accurate in vitro testing
- Comprehensive data: 40+ variables per patient, with initial focus on colorectal and pancreatic cancers
Two-Pronged Commercial Strategy
With €15 million in total funding (including recent seed rounds and Bpifrance support), Orakl is preparing to launch:
- O-Predict: Helps drug developers forecast patient responses to experimental treatments
- O-Validate: Enables biotech firms to validate their AI-driven discoveries
The Bigger Picture
For Jaulin, the mission transcends business metrics. As cancer increasingly becomes a chronic condition, she sees an urgent need to:
- Expand the therapeutic arsenal
- Streamline precision medicine development
- Accelerate life-saving treatments to patients
“Our ultimate goal,” she emphasizes, “is to unlock the drug discovery process to help as many patients as possible.”
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