Endeavor BioMedicines Emerges with $62M Series A to Tackle Pulmonary Fibrosis
Biotech startup Endeavor BioMedicines has officially launched with a $62 million Series A funding round, led by prominent investors Omega Funds and Longitude Capital, alongside contributions from its management team. The San Diego-based company aims to revolutionize treatment for debilitating pulmonary diseases, with an immediate focus on idiopathic pulmonary fibrosis (IPF).
Leadership with Proven Track Records
- John Hood, Endeavor’s CEO and co-founder, previously led Impact Biomedicines (acquired by Celgene for up to $7B)
- Miguel de los Rios, CSO and co-founder, brings expertise from his tenure as CEO of Rift Biotherapeutics
Targeting a Deadly Lung Disease
IPF affects over 100,000 Americans, causing progressive lung scarring with:
- Alarming prognosis: 2-5 year average survival post-diagnosis
- Limited treatment options: Current therapies only slow progression
The Science Behind the Solution
Endeavor’s lead candidate, taladegib, is a hedgehog pathway inhibitor with a unique approach:
- Mechanism: Targets cellular pathways involved in tissue regeneration
- Potential: May reverse or significantly slow IPF progression
- Clinical Stage: Currently in Phase 2 trials
“Our goal isn’t just management—we’re aiming to change the disease trajectory,” emphasized CEO John Hood.
Why This Matters
- Unmet medical need: IPF claims 40,000+ lives annually in the U.S.
- Scientific innovation: Hedgehog pathway represents a novel therapeutic target
- Experienced team: Leadership with prior successful biotech exits
The funding will accelerate two Phase 2 clinical trials evaluating taladegib’s efficacy in IPF patients, with results expected within 24 months. This development marks a significant step forward in pulmonary medicine, offering hope where treatment options remain severely limited.
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